METHOD FOR TREATING ONCOLOGICAL DISEASES Russian patent published in 2018 - IPC A61K31/535 A61K31/713 A61K48/00 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine. Proposed is a method for treating oncological diseases. Initially, tumor cells are introduced into the primary culture and treated once with cross-linking cytostatic at a dose corresponding to 1/3 of the total single clinical dose of the cytostatic. Profile of the tumor cell reparative cycle in the patient is determined. Day of the synchronization in the sensitive G1/S phase of the cell cycle and the maximum accumulated number of stem initiating tumor cells of the tumor is determined. Number of stem initiating tumor cells and cell cycle distribution is determined daily by FACS analysis and cytologically by the TAMRA internalization of the labelled DNA-probe into these cells, on the basis of which the day of the maximum accumulation of TAMRA positive cells which corresponds to their synchronization in the therapy sensitive phase of the cell cycle is determined. Cytotoxic is administered four times by three treatments at the indicated doses. Double-stranded DNA preparation is administered four times after each injection of the cytostatic at a time point of demarcation at a dose of 10–20 mg per 1 kg of body weight, intraperitoneally or intramuscularly, or inside the tumor.

EFFECT: invention provides a wider application of the treatment method and higher treatment efficiency.

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