METHOD OF DETERMINING PHYSICAL-BIOLOGICAL PARAMETERS OF SKIN AND CONCENTRATION OF HAEMOGLOBIN DERIVATIVES IN BLOOD Russian patent published in 2015 - IPC G01N33/49 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine and can be applied in medical diagnostics and therapy. A method of determining physical-biological parameters of skin and the concentration of haemoglobin derivatives in blood includes sending onto the skin polarised optical irradiation with a known spectrum, registration of signals of light diffusively-reflected by the skin with the polarisation, orthogonal to the polarisation of the sent onto skin radiation. Optical radiation is focused onto the skin surface into an irradiation spot, signals of light diffusively-reflected by the skin P(ρ, λ) in the spectral range λ=450-800 nm not less than from two ring areas on the skin surface, located at different distances ρ from the irradiation spot, are registered. Then the difference signals r(ρ, λ)=ln(P(ρ₀, λ)/P(ρ, λ)) are determined, where ρ₀ is a distance to the registration ring nearest to the irradiation spot, and the physical-biological parameters of the skin and the concentration of haemoglobin derivatives are determined by solution of an inverse problem with the application of analytical expressions, which approximate the dependence r(ρ, λ) on the determined parameters.

EFFECT: invention ensures accurate determination of parameters without the necessity to carry out calibrating changes and the increase of quantity of the determined parameters.

6 dwg,1 tbl