BIOSENSOR Russian patent published in 2015 - IPC G01N33/543 G01N27/327 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the field of medicine and can be applied for the detection of a target molecule in a biological sample. A sensor for detecting the target of interest contains: the first electrode; the first molecule with electronic conductivity, configured for binding with the first electrode; the first probe, conjugated with the second molecule with electronic conductivity; the second electrode; the third molecule with electronic conductivity, configured for binding with the second electrode; the second probe, conjugated with the third molecule with electronic conductivity. The first probe is configured for binding with the target of interest in a solution, the second probe does not bind with the target, and the first and second molecules with electronic conductivity differ from each other. The group of inventions also relates to a method of detecting the target of interest, which includes contact of the said sensor with the sample, generation of the first signal when the target binds with the first probe and the second signal without binding of the target with the second probe. The target is detected by the comparison of the first and second signal value with a specified value, indicating the presence of the target in the sample.

EFFECT: group of inventions provides an increased accuracy of detecting the target molecule in a biological sample.

42 cl, 12 dwg, 3 ex