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2 546 111

(13)

(51)

IPC

C07C231/02(2006-01-01)

C07C233/25(2006-01-01)

C07C209/36(2006-01-01)

(21) (22)

Application

2012130826/04, 2012-07-18

(24)

Start date

2012-07-18

(22)

Actual filing date

2012-07-18

(45)

Published

2015-04-10

(72)

Inventor

Azev Jurij AlekseevichCharushnikov Kirill AleksandrovichMokrushin Vladimir StepanovichBakulev Vasilij Alekseevich

(73)

Holder

Federal'Noe Gosudarstvennoe Avtonomnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Federal'Nyj Universitet Imeni Pervogo Prezidenta Rossii B.N. El'Tsina"

METHOD OF PHENACETIN OBTAINING Russian patent published in 2015 - IPC C07C231/02 C07C233/25 C07C209/36

Abstract RU 2546111 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method of obtaining phenacetin. The method is realised by the reduction of p-ethoxynitrobenzene, carried out in isopropyl alcohol with mixing with the catalyst Raney Ni under hydrogen pressure of 2-4 atm at 60-70°C in the presence of acetic anhydride, acylation of the formed p-ethoxyaniline and separation of the target product.

EFFECT: improvement of the technology of phenacetin synthesis due to the realisation of the hydration and acylation processes in one reactor without the separation of intermediate p-ethoxyaniline and application of gaseous hydrogen as a reducing agent, which makes it possible to simplify the separation and purification of the target product and increase its quality.

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RU 2 546 111 C2

Authors

Azev Jurij Alekseevich

Charushnikov Kirill Aleksandrovich

Mokrushin Vladimir Stepanovich

Bakulev Vasilij Alekseevich

Dates

2015-04-10—Published

2012-07-18—Filed