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2 548 734

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IPC

A61K9/08(2006-01-01)

A61K31/195(2006-01-01)

A61K33/14(2006-01-01)

A61P9/00(2006-01-01)

(21) (22)

Application

2013141613/15, 2013-09-11

(24)

Start date

2013-09-11

(22)

Actual filing date

2013-09-11

(45)

Published

2015-04-20

(72)

Inventor

Bokerija Leonid AntonovichBoldyrev Aleksandr AleksandrovichMovsesjan Ruben Rudol'FovichKulaga Olesja IgorevnaPopov Aleksej Evgen'EvichEgorov Dmitrij NikolaevichArzumanjan Elena Sergeevna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Tsentr Serdechno-Sosudistoj Khirurgii Imeni A.N. Bakuleva" Rossijskoj Akademii Meditsinskikh Nauk

CARDIOPLEGIC "BOKERIA-BOLDYREV" SOLUTION Russian patent published in 2015 - IPC A61K9/08 A61K31/195 A61K33/14 A61P9/00

Abstract RU 2548734 C2

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to cardiac surgery, and represents cardioplegic solution, which contains sodium chloride - 3.41-3.62, potassium chloride - 1.092-1.156 g, magnesium chloride - 3.190-3.485 g, calcium gluconate - 0.0105-0.0130 g, mannite - 4.365-4.520 g, L-carnosine - 20.1504-24.1650 g, N-acetylcarnosine - 8.056-11.032 g, L-histidine - 0.705-0.820 g, water for injections to 1000 ml.

EFFECT: invention ensures prevention of reduction of amplitude, speed of front and speed of pulse-wave reduction, as well as increase of diastolic pressure in left heart ventricle during reperfusion with preservation of buffer capacity and osmolarity of cardioplegic solution with physiological pH parameters.

4 tbl, 2 ex

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RU 2 548 734 C2

Authors

Bokerija Leonid Antonovich

Boldyrev Aleksandr Aleksandrovich

Movsesjan Ruben Rudol'Fovich

Kulaga Olesja Igorevna

Popov Aleksej Evgen'Evich

Egorov Dmitrij Nikolaevich

Arzumanjan Elena Sergeevna

Dates

2015-04-20—Published

2013-09-11—Filed