OBTAINING N-MONO FLUOROALKYL TROPANES Russian patent published in 2015 - IPC C07D451/02 C07B59/00 A61K51/04 A61K101/02 

FIELD: chemistry.

SUBSTANCE: invention relates to synthesis of N-mono fluoroalkyl tropanes with application of fluoroalkyliodides, as well as to application of such method for obtaining non-radioactive tropane intermediate compound of formula and its further conversion into ¹²³I-labelled radiopharmaceutical substance DaTSCAN (¹²³I-ioflupane). Method consists in alkylation in presence of base of formula compound with alkylating agent of formula F-(CH₂)_mX, where m equals 2, 3 or 4, X represents I. .

EFFECT: obtaining non-radioactive tropane intermediate compound of formula and its further conversion into ¹²³I-labelled radiopharmaceutical substance DaTSCAN (¹²³I-ioflupane).

10 cl, 1 ex