MIXED COBALT (II) SALTS OF KETOCARBOXYLIC AND MERCAPTOCARBOXYLIC ACIDS AND HYDRATES THEREOF, OR SOLVATES THEREOF, METHODS FOR PRODUCTION AND USE THEREOF AS CYANIDE ANTIDOTES Russian patent published in 2015 - IPC C07C321/02 C07C59/347 C07F15/06 A61K31/295 A61P39/02 

Abstract RU 2553275 C2

FIELD: chemistry.

SUBSTANCE: invention relates to mixed cobalt (II) salts of ketocarboxylic and mercaptocarboxylic acids of general formula (I):

where R=Alk, R'=H, Alk, NH2, NHCOCH3, m=0-3, R"=H, Alk, COOH, n=0-3, where Alk=alkyl C1-C3, or to such compounds as a cobalt (II) salt of mercaptoacetic acid and pyruvic acid, a cobalt (II) salt of mercaptoacetic acid and α-ketoglutaric acid, a cobalt (II) salt of N-acetyl-L-cysteine and pyruvic acid, a cobalt (II) salt of α-ketoglutaric acid and L-cysteine, a cobalt (II) salt of pyruvic acid and 2-mercaptopropionic acid or hydrates or solvates thereof. A method of producing salts of general formula (I) is also disclosed.

EFFECT: invention enables to obtain mixed cobalt (II) salts of ketocarboxylic and mercaptocarboxylic acids, having cyanide antidote activity.

7 cl, 7 ex

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Authors

Kovtun Valerij Juzefovich

Davidovich Jurij Aleksandrovich

Nazarov Viktor Borisovich

Gladkikh Vadim Dmitrievich

Chikunov Il'Ja Evgen'Evich

Melikhova Marina Valentinovna

Kolbasov Sergej Evgen'Evich

Nechiporenko Sergej Petrovich Umer

Dates

2015-06-10Published

2013-10-04Filed