MIXED COBALT (II) SALTS OF KETOCARBOXYLIC AND MERCAPTOCARBOXYLIC ACIDS AND HYDRATES THEREOF, OR SOLVATES THEREOF, METHODS FOR PRODUCTION AND USE THEREOF AS CYANIDE ANTIDOTES Russian patent published in 2015 - IPC C07C321/02 C07C59/347 C07F15/06 A61K31/295 A61P39/02 

Abstract RU 2553275 C2

FIELD: chemistry.

SUBSTANCE: invention relates to mixed cobalt (II) salts of ketocarboxylic and mercaptocarboxylic acids of general formula (I):

where R=Alk, R'=H, Alk, NH2, NHCOCH3, m=0-3, R"=H, Alk, COOH, n=0-3, where Alk=alkyl C1-C3, or to such compounds as a cobalt (II) salt of mercaptoacetic acid and pyruvic acid, a cobalt (II) salt of mercaptoacetic acid and α-ketoglutaric acid, a cobalt (II) salt of N-acetyl-L-cysteine and pyruvic acid, a cobalt (II) salt of α-ketoglutaric acid and L-cysteine, a cobalt (II) salt of pyruvic acid and 2-mercaptopropionic acid or hydrates or solvates thereof. A method of producing salts of general formula (I) is also disclosed.

EFFECT: invention enables to obtain mixed cobalt (II) salts of ketocarboxylic and mercaptocarboxylic acids, having cyanide antidote activity.

7 cl, 7 ex

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RU 2 553 275 C2

Authors

Kovtun Valerij Juzefovich

Davidovich Jurij Aleksandrovich

Nazarov Viktor Borisovich

Gladkikh Vadim Dmitrievich

Chikunov Il'Ja Evgen'Evich

Melikhova Marina Valentinovna

Kolbasov Sergej Evgen'Evich

Nechiporenko Sergej Petrovich Umer

Dates

2015-06-10Published

2013-10-04Filed