DIAGNOSTIC TECHNIQUE FOR COBALT-INDUCED NEPHROPATHY IN EXPERIMENTAL ANIMALS SUFFERING CHRONIC POISONING Russian patent published in 2011 - IPC G01N33/48 A61P39/00 

FIELD: medicine.

SUBSTANCE: diagnostic technique for cobalt-induced nephropathy in experimental animals suffering chronic poisoning, involves examination of the animals for erythrocyte and renal tissue malondialdehyde (MDA) concentration and simultaneously, for Na+, K+-ATP-ase activity in renal tissue, and if the MDA values are within the range 4.96±0.03 to 5.32±0.06 nmol/ml of erythrocyte mass and more, and in cortical and medullary substance cells of renal tissue respectively within the range 2.49±0.12 to 2.87±0.06 and 4.56±0.06 to 5.25±0.08 nmol/mg of protein and more, and the Na+, K+-ATP-ase activity values of the cortical and medullary substance of renal tissue within 2.08±0.03 to 1.31±0.14 and 5.28±0.18 to 3.92±0.02 mcmole Rn/mg protein/hour and less respectively, cobalt-induced nephropathy is diagnosed.

EFFECT: technique allows extending a notion of pathogenetic mechanisms of nephropathy development with underlying chronic cobalt-induced intoxication in experimental animals.

5 tbl, 1 ex