OCTAPEPTIDE FOR PRODUCING RADIOTRACERS, RADIOTRACER BASED THEREON METHOD OF DIAGNOSING TUMOURS, EXPRESSING SOMATOSTATIN RECEPTORS Russian patent published in 2012 - IPC C07K7/06 C07K14/655 A61K38/08 A61K38/31 A61K51/08 

FIELD: chemistry.

SUBSTANCE: invention relates to octapeptides of formula (I), where X and Y=H or a chelating group, particularly DOTA, covalently bonded with α- or ε-amino groups of N-terminal lysine, which are octreotide derivatives, as well as radiotracers based thereon, used in tumour diagnosis. The octapeptide of formula (I) forms a chelate complex with radionuclides, for example in form of gallium isotopes ⁶⁸Ga, ⁶⁶Ga, ⁶⁷Ga to obtain a radiopharmaceutical complex. The radiotracer is used for diagnosis of tumours expressing somatostatin receptors or metastases thereof.

EFFECT: improved method.

4 cl, 8 ex, 3 tbl, 1 dwg