METHOD FOR PRODUCING AND INDUCING TARGETED DIFFERENTIATION OF PULMONARY PLURIPOTENT CELL CULTURE Russian patent published in 2015 - IPC C12N5/02 C12N5/07 

Abstract RU 2554843 C2

FIELD: medicine.

SUBSTANCE: invention refers to biotechnology and medicine. What is presented is a method for differentiation of mesenchymal stem cells of fibrotic lungs into fibroblastic cells, characterised by recovering the cells self-maintaining in vitro for 60 days and having mesenchymal stem cell phenotype (CD44+, CD73+, CD90+, CD106+, CD31-, CD34-, CD45-) from the right lobe of fibrotic lungs and producing the fibroblastic cells when adding fibroblast growth factor 2 mcg/ml to the mesenchymal stem cell culture.

EFFECT: method enables producing the donor cells from the patients suffering idiopathic fibrosis from fibrotic pulmonary tissues.

3 dwg, 1 ex

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RU 2 554 843 C2

Authors

Dygaj Aleksandr Mikhajlovich

Skurikhin Evgenij Germanovich

Pershina Ol'Ga Viktorovna

Khmelevskaja Ekaterina Sergeevna

Krupin Vjacheslav Andreevich

Ermakova Natalija Nikolaevna

Reztsova Alena Mikhajlovna

Dates

2015-06-27Published

2013-08-08Filed