HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES HAVING 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING Russian patent published in 2015 - IPC C07D498/04 A61K31/519 A61P17/02 A61P43/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to oxazolopyrimidine compounds of formula , wherein A is specified in O or S; X is specified in (C₁-C₆)-alkanediyl, (C₂-C₆)-alkenediyl and (C₁-C₆)-alkanediyl-oxy, wherein an oxygen atom of (C₁-C₆)-alkanediyl-oxy group is bound to the group R²; Y represents a 4-7-merous saturated monocyclic heterocycle; R¹ represents hydrogen; R² is specified in phenylene, which is optionally substituted by one or two identical or different substitutes R²²; R³ is specified in phenylene and thiazole, wherein a ring residue is optionally substituted by identical or different substitutes R³¹ at one or two carbon atoms of the ring; R²² is specified in halogen and (C₁-C₄)-alkyl-, which is optionally substituted by 1-3 fluorine atoms; R³¹ is specified in halogen, (C₁-C₄)-alkyl and (C₁-C₄)-alkyloxy. The invention also refers to a method for producing the compounds of formula I and to a pharmaceutical composition applicable for activating EDG-1 receptor.

EFFECT: compounds of formula I applicable for activating EDG-1 receptor and for treating disturbed wound healing and diabetic foot.

18 cl, 2 tbl, 37 ex