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2 557 891

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IPC

A61K31/4409(2006-01-01)

A61K31/721(2006-01-01)

(21) (22)

Application

2014121240/15, 2014-05-26

(24)

Start date

2014-05-26

(22)

Actual filing date

2014-05-26

(45)

Published

2015-07-27

(72)

Inventor

Zharkov Aleksandr SergeevichPevchenko Boris Vasil'EvichBeljaev Vjacheslav NikolaevichFrolov Aleksandr Valer'EvichBezgodova Ol'Ga Aleksandrovna

(73)

Holder

Aktsionernoe Obshchestvo Nauchno-Proizvodstvennyj Tsentr

METHOD OF OBTAINING SUBSTANCE BASED ON OXIDATED DEXTRAN AND ISONICOTINIC ACID HYDRAZIDE Russian patent published in 2015 - IPC A61K31/4409 A61K31/721

Abstract RU 2557891 C1

FIELD: chemistry.

SUBSTANCE: invention represents method of obtaining substations based on oxidated dextran and isonicotinic acid hydrazide, which includes obtaining dextran water solution, dextran oxidation with potassium permanganate in acidic medium at heating, removal of admixtures from solution by filtration, purification of oxidated dextran water solution from manganese ions by passing at rate 100-600 ml/min through cation exchange resin, represented by cationite based on styrene copolymer with static volume capacity 1.9 g-eq/cm³, addition of powder of isonicotinic acid hydrazide and distilled water or water solution of isonicotinic acid hydrazide.

EFFECT: simplification of process of obtaining substance based on oxidated dextran and isonicotinic acid hydrazide for pharmaceutical application due to creation of conditions for minimisation of stages and used reagents with elimination of application of dangerous reagents and simultaneous obtaining target product, free of manganese ions.

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RU 2 557 891 C1

Authors

Zharkov Aleksandr Sergeevich

Pevchenko Boris Vasil'Evich

Beljaev Vjacheslav Nikolaevich

Frolov Aleksandr Valer'Evich

Bezgodova Ol'Ga Aleksandrovna

Dates

2015-07-27—Published

2014-05-26—Filed