FIELD: organic chemistry, chemistry of high-molecular compounds, biochemistry. SUBSTANCE: method involves oxidation of dextran with sodium periodate, precipitation with ethanol, conjugation of obtained dialdehyde dextran with isoniazid and reduction of Schiff's base formed with sodium boron hydrode. Before precipitation with ethanol dialysis of dialdehyde dexran is carried out. Conjugation is carried out by addition of isoniazid as a dry substance at amount providing its concentration 0.3 mole/l. Dialysis of conjugate solution is carried out before its precipitation with ethanol. Invention can be used in development of new antituberculosis drugs of enhanced effectiveness. EFFECT: increased content of isoniazid, high purity and stability of product.
| Title | Year | Author | Number |
|---|---|---|---|
| ISONIAZID-DEXTRAN CONJUGATE AND APPLICATION THEREOF | 1999 |
|
RU2163120C1 |
| METHOD OF TREATMENT THE GENERAL TUBERCULOSIS PROCESS IN EXPERIMENT | 1993 |
|
RU2087146C1 |
| AGENT WITH LOW HEPATOTOXICITY FOR TREATMENT OF TUBERCULOSIS PATIENTS | 1999 |
|
RU2168994C1 |
| AGENT FOR TREATMENT OF TUBERCULOSIS WITH LOW LEVEL OF FIBROTIC COMPLICATIONS | 2000 |
|
RU2185166C2 |
| METHOD OF PREPARING ISONIAZID WITH PROLONGED EFFECT | 1999 |
|
RU2143900C1 |
| METHOD OF OBTAINING SUBSTANCE BASED ON OXIDATED DEXTRAN AND ISONICOTINIC ACID HYDRAZIDE | 2014 |
|
RU2557891C1 |
| METHOD FOR PREPARING BIOTINYLATED DERIVATIVE OF OXIDISED DEXTRAN | 2013 |
|
RU2537246C1 |
| METHOD FOR OXIDIZED DEXTRAN OBTAINING | 2016 |
|
RU2618341C1 |
| PHARMACEUTICAL TUBERCULOSIS COMPOSITION | 2008 |
|
RU2372914C1 |
| METHOD FOR PRODUCING NANOPARTICLES OF POLYSACCHARIDES | 2013 |
|
RU2632019C2 |
