METHOD OF PREDICTING LEVEL OF ARTERIAL PRESSURE IN WOMEN IN LATE PREGNANCY Russian patent published in 2015 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: invention deals with method of predicting level of arterial pressure in women of Russian nationality, born in Central Black Earth region of Russia. Method includes separation of DNA from lymphocytes of peripheral venous blood and analysis of genetic polymorphisms. +46G/A ADRB2 and 4a/4b eNOS by method of polymerase chain reaction Level of systolic arterial pressure in women in late pregnancy is predicted by results of multiple regression equation of the following type: Y₁=15,455+2,544x₁+9,946x₂+0,736x₃+4,716x₄+0,185x_5, where x₁ is genetic variant in locus - 4a/4b eNOS, namely 4b4b=1; 4a4b=2; 4a4a=3; x₂ is presence of preeclampsia in relatives: yes=0, no=1; x₃ is level of systolic arterial pressure before pregnancy, mm Hg; x₄ is presence of cardiovascular system pathology: yes=0, no=1; x₅ is woman's weight before pregnancy, kg Level of diastolic arterial pressure in women in late pregnancy is predicted, for which purpose multiple regression equation of the following type is used: Y₂=14,200+7,768x₁-2,877x₂+7,500x₃+0,414x₄+3,668x_5, where x₁ is genetic variant in locus - 4a4b eNOS, namely 4b4b+4a4b=1, 4a4a=0; x₂ is genetic variant in locus +46G/A ADRB2, namely GG+GA=1, AA=0; x₃ is presence of preeclapsia in relatives:yes=0, no=1; x₄ is systolic arterial pressure before pregnancy, mm Hg; x₅ is presence of cardiovascular system pathology: yes=0, no=1.

EFFECT: invention makes it possible to realise early prediction of increase of arterial pressure level in women in late pregnancy, will make it possible to form of women at the stage of pregravidal preparation and at early terms of pregnancy groups of high risk of developing hypertension in late pregnancy, as well as realise required therapeutic-preventive measures aimed at prevention of development of said pregnancy complication in due time.

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