METHOD FOR PREDICTION OF HYPERTENSION COMPLICATIONS OF PREGNANCY IN PATIENTS SUFFERING FROM GESTATIONAL DIABETES MELLITUS Russian patent published in 2014 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: method is based on measuring the following parameters: AGT gene 704C version allele: (704TC or 704CC genotype), AGT gene 521T version allele (521CT or 521TT genotype), AGTR1 gene 1166C version allele (1166AC or 1166CC genotype), NOS3 gene 786C version allele (786TC or 786 CC genotype). There are also specified: the age of 35 and older, a bid foetus in past medical history, a patient's BWI ≥40 kg/m², cardiovascular pathologies in relatives. That is followed by calculating a prognostic index by the formula: P=0.861 × X1+0.636 × X2+0.271 × X3+0.793 × X4+1.487 × X5+0.822 × X6+0.869 × X7+0.801 × X8 - 2.421, wherein X1 is AGT gene C allele (polymorphism 704 T>C) in the genotype (yes -1, no - 0). X2 is AGT gene T allele (polymorphism 521 C>T) in the genotype (yes -1, no - 0). X3 is AGT gene T allele (polymorphism 1166 C>T) in the genotype (yes -1, no - 0). X4 is NOS3 gene C allele (polymorphism 786 C>T) in the genotype (yes -1, no - 0). X5 is the age of 35 and older (yes -1, no - 0). X6 is a big foetus in past medical history (yes -1, no - 0). X7 is the patient's BWI >40 kg/m (if >40 kg/m -1, if not - 0). X8 is a cardiovascular pathology in relatives (yes -1, no - 0). Const=-2.42129. If P<0, no risk of developing hypertension complications is stated. If P>0, developing hypertension complications are predicted.

EFFECT: invention has high sensitivity, specificity, and efficiency; this formula enables predicting developing hypertension complications prior to clinical manifestations.

2 ex