METHOD OF PRODUCING BIOCOMPATIBLE NANOPOROUS SPHERICAL PARTICLES OF SILICON OXIDE WITH CONTROLLED EXTERNAL DIAMETER (VERSIONS) Russian patent published in 2015 - IPC C01B33/12 C01B33/18 B82B3/00 B82Y30/00 B82Y40/00 

FIELD: chemistry.

SUBSTANCE: method of producing biocompatible nanoporous spherical particles of silicon oxide includes synthesis in a reaction mixture of tetraethoxysilane (TEOS) with NH₃, water (H₂O), alcohol (C₂H₅OH) and cetyltrimethylammonium bromide (C₁₆H₃₃N(CH₃)₃Br - CTAB) in molar ratio TEOS:NH₃:H₂O:C₂H₅OH:CTAB of 1:19:370:230:0.2, with intense stirring at a rate of 125-250 min^-1 at temperature of 5-80°C for 2-3 hours to form, during hydrolysis of TEOS in an alcohol-water-ammonia medium, orthosilicic acid Si(OH)₄ monomers, condensation of the monomers to form primary particles with size of 3-5 nm, coagulation of said particles, after which the obtained particles are roasted in air at temperature of 550°C for 15 hours to remove organic substances. In another version, nanoporous silicon oxide particles are obtained by synthesis using cetyltrimethylammonium bromide C₁₆H₃₃N(CH₃)₃Br (CTAB) with concentration of up to 0.007 mol.·l^-1 as a structure-forming agent, wherein synthesis is carried out via hydrolysis of tetraethoxysilane (Si(OC₂H₅)₄ - TEOS) in a CTAB-ethanol-water-ammonia medium at temperature of 5-80°C for 2-3 hours with molar ratio TEOS:NH₃:H₂O:C₂H₅OH:CTAB of 1:19:370:230:0.2, thereby forming, in the reaction mixture, cylindrical micelles coated with a layer of SiO₂, which are organised into blocks, and then roasting the obtained materials at 550°C to remove organic substances and obtain nanopores inside the spherical particles.

EFFECT: obtaining biocompatible nanoporous spherical silicon oxide particles with a controlled external diameter, having a regular channel internal structure.

2 cl, 10 dwg, 2 ex