FIELD: immunology.
SUBSTANCE: disclosed are peptides derived from FOXM1 and capable of inducing a cytotoxic T-cell (CTL) in the presence of an antigen-presenting cell (APC) expressing HLA-A*01:01. Invention also describes: a coding polynucleotide; composition; methods for inducing APC and CTL; APC presenting HLA-A*01:01 and peptide; a method for inducing an immune response; method of treating and/or preventing a malignant tumor and/or preventing its postoperative recurrence; emulsion; set; as well as use of said inventions when preparing a pharmaceutical composition and a peptide screening method with ability to induce CTL.
EFFECT: this group of inventions can find application in therapy of diseases associated with FOXM1.
21 cl, 8 dwg, 2 tbl, 3 ex
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Authors
Dates
2020-12-14—Published
2016-10-06—Filed