METHOD FOR DIFFERENTIATION STAGE-RELATED HEPATOCARCINOMA CELLS EXPOSURE TO LITHIUM NANOPREPARATIONS Russian patent published in 2015 - IPC A61K33/00 B82B1/00 

FIELD: medicine.

SUBSTANCE: invention refers to developing a targeted therapy of the tumour growth. What is disclosed is a method for differentiation stage-related hepatocarcinoma cell exposure to various lithium nanopreparations: nanosized lithium carbonate having a particle size of 10 nm taken as suspension in normal saline and injected intramuscularly to ensure the cytotoxic effect on the tumour cells of the 4^th and 5^th differentiation stages, and nanosized lithium citrate having a particle size of 10 nm dissolved in normal saline and administered intraperitoneally to provide the cytostatic effect on the tumour cells of the 1^st-3^rd differentiation stages. The differentiation stages are determined by light microscopy showing a nuclear-cytoplasmic ratio.

EFFECT: method for the hepatocarcinoma cell exposure provides the targeted exposure covering the hepatocarcinoma target cells of the specific differentiation stage.

1 dwg, 7 ex