FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to novel compounds of formula (I), possessing affinity with respect to a nicotinic acetylcholine receptor and selective activity with respect to the acetylcholine receptor α3β4. In formula (I)
R1 represents hydrogen, (C1-C4)alkyl, cyclopropylmethyl, (C1-C4)alkenyl, phenyl-(C1-C4)alkyl, phenyl-(C1-C4)alkenyl or phenyl-(C1-C4)heteroalkyl, where phenyl in the said phenyl-(C1-C4)alkyl, phenyl-(C1-C4)alkenyl and phenyl-(C1-C4)heteroalkyl is possibly substituted with halogen, (C1-C4)alkyl, (C1-C4)alkoxy, nitro, cyano, trifluoromethyl or trifluoromethoxy, and where a heteroatom, included in the said (C1-C4)heteroalkyl, represents oxygen; Y represents -NR3; R3 represents hydrogen or (C1-C4)alkyl; X represents ortho-substituted phenyl, substituted with halogen, (C1-C4)alkyl, (C1-C4)alkoxy, nitro, cyano, trifluoromethyl, trifluoromethoxy or -C(O)-phenyl.
EFFECT: compounds can be applied in the treatment, prevention or attenuation of symptoms of various medical disorders, such as pain, narcotic addiction, selected from cocaine, opiate, marijuana, or nicotine, alcohol, amphetamine addiction.
16 cl, 1 tbl, 3 ex
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