FIELD: medicine.
SUBSTANCE: studying formation and progression of liver changes caused by toxic-chemical disturbing factors is ensured by the presented method for simulating a sub-acute toxic liver involvement. The method involves administering formaline into male rats orally during 21 days. The administration is performed every second day at 0.2 ml per 100 g of animal's body weight. That is combined with the exposure to 10% ethanol used as drinking water taken by animals infinitely.
EFFECT: method provides developing the pronounced degenerative involvement of almost all liver portions that is proved by higher blood serum transaminases, creatininemia, depression of synthetic ability and developing cholestasis.
1 tbl, 3 ex
| Title | Year | Author | Number |
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| METHOD OF TREATING LIVER DISEASES OF VARIOUS GENESES | 2009 |
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| (Z)-METHYL-16-(5-OXO-2-PHENYL-OXAZOL-4-ILIDENMETHYL)-15,16-EPOXY-8(17),13(16),14-LABDATRIEN-18-OATE, POSSESSING ANTIOXIDATIVE, HEPATOPROTECTIVE AND HEMOSTIMULATING ACTIVITY | 2007 |
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