FIELD: medicine.
SUBSTANCE: formalin (CH2O) is used, which is injected orally to male rats every day, at the rate of 0.1 ml per 100 g of animal weight, for 14 days. On day 14, animals are decapitate with subsequent laboratory tests and liver study. The model of subacute lesions caused by the oral introduction of formalin (CH2O) is obtained, represented by increased degenerative processes in the liver, evolving creatininemia, increased transaminase level, development of cholestasis, and histologically proven by expressed degenerative damages of almost all sites of the liver.
EFFECT: method allows to obtain a model of subacute liver damage to be used in an experiment.
2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR SIMULATING TOXIC HEPATITIS WITH FORMALINE AND ETHANOL IN TOXICOLOGY TEST | 2014 |
|
RU2564758C1 |
| METHOD FOR SIMULATING CHRONIC FORMALIN INTOXICATION IN TOXICOLOGICAL EXPERIMENT | 2014 |
|
RU2564761C1 |
| METHOD FOR SIMULATING CARBON TETRACHLORIDE-INDUCED TOXIC DAMAGE IN TOXICOLOGICAL EXPERIMENT | 2011 |
|
RU2487421C1 |
| METHOD FOR SIMULATING ACUTE LIVER DISEASE IN PREGNANT WOMEN | 2015 |
|
RU2610536C1 |
| METHOD OF MODELLING CHRONIC TOXIC HEPATOPATHY | 2010 |
|
RU2440621C1 |
| COMPOSITION AND USING COMPOSITION FOR PREPARING DRUG HAVING HEPATOPROTECTIVE ACTIVITY | 2012 |
|
RU2485970C1 |
| ORAL PHARMACEUTICAL COMPOSITION FOR TREATING INFLAMMATORY GASTROINTESTINAL DISEASES | 2010 |
|
RU2445965C2 |
| USING ACIZOL AS HEPATOPROTECTING AGENT | 2004 |
|
RU2260427C1 |
| METHOD OF SIMULATING MULTIPLE ORGAN PATHOLOGY IN RATS | 2011 |
|
RU2453002C1 |
| METHOD OF MODELING NON-ALCOHOLIC STEATOHEPATITIS IN RATS | 2009 |
|
RU2394281C1 |
