FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine, and concerns a method for producing [Ac-225]-p-SCN-Bn-DOTA/HuM195 radioimmunoconjugate (radioimmunoconjugate Ac-225), involving the stages of conjugating p-SCN-Bn-DOTA with anti-HuM195 antibody in a conjugating reaction mixture for producing a conjugated biological molecule, purifying the reaction mixture for removing non-conjugated chelating agents, and chelating one or more Ac-225 radionuclides with conjugated p-SCN-Bn-DOTA/HuM95 in the chelating reaction mixture for producing Ac-225 radioimmunoconjugate. The group of inventions also concerns the radioimmunoconjugate Ac-225 produced according to the above method.
EFFECT: group of inventions provides higher end product yield.
20 cl, 4 ex, 14 dwg, 5 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHODS FOR PRODUCING RADIOIMMUNOCONJUGATES | 2010 |
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| PARAMINOHYPURIC ACID (PAH) AS A KIDNEY PROTECTOR | 2020 |
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| COMPLEX COMPOUNDS CONTAINING RADIONUCLIDE Th, AS WELL AS BISPHOSPHONATE FRAGMENT, METHODS FOR THEIR PRODUCTION, AS WELL AS POTENTIAL USE AS ACTIVE SUBSTANCE IN COMPOSITION OF OSTEOTROPIC RADIOPHARMACEUTICAL DRUG | 2020 |
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RU2767567C1 |
