FIELD: chemistry.
SUBSTANCE: invention relates to biotechnology and particularly to conjugates of Apo A with therapeutic polypeptides, and can be used in medicine. A conjugate is obtained, having an Apo A-I molecule or a functionally equivalent version thereof, such as Apo A-IV or Apo A-V, covalently bonded to the polypeptide of therapeutic interest, which is selected from interferon, TGF-beta inhibitor P144 or P17, IL-15, cardiotrophin-1, porphobilinogen deaminase, insulin and factor VII.
EFFECT: obtained conjugate prolongs the half-life of a therapeutic polypeptide administered to an individual, and also enables delivery thereof to those tissues having specific binding sites for the Apo A molecule.
32 cl, 16 dwg, 1 tbl, 15 ex
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