METHOD AND FORMULATION FOR PRODUCING 99m TC LABELLED 5-THIO-D-GLUCOSE AGENT FOR RADIONUCLIDE DIAGNOSIS Russian patent published in 2015 - IPC A61K47/12 A61K51/04 A61K103/10 

FIELD: medicine.

SUBSTANCE: method for producing 99m Tc-labelled 5-thio-D-glucose agent for radionuclide diagnosis involves producing a reaction mixture consisting of glucose derivative, tin (II) chloride dehydrate, hydrochloric acid and ascorbic acid in 1 ml of the solution, filtering and sterilising the produced solution and lyophilising the agent and sealing it in a bottle; the mixture is lyophilised without pre-freezing in liquid nitrogen. The reaction mixture contains 5-thio-D-glucose and water for injections in the following proportions: 5-thio-D-glucose 15 mg, tin (II) chloride dehydrate 0.150-0.175 mg, 0.05 M hydrochloric acid 200 mcl (0.36 mg), ascorbic acid 0.5 mg and water for injections 1 ml.

EFFECT: creating the standard storage-stable formulation for producing the 99mTc-5-thio-D-glucose radiopharmaceutical to image a tumour by means of SPECT gamma-chamber and visualise biochemical changes of metabolism that is expected to promote accurate diagnosing and effective treatment of tumours.

2 cl, 2 ex, 3 dwg, 1 tbl