METHOD OF OBTAINING REAGENT FOR PREPARATION OF RADIOPHARMACEUTICAL BASED ON TECHNETIUM-99m-LABELLED CIPROFLOXACIN WITH PRESERVATION OF ITS STABILITY IN LONG-TERM STORAGE Russian patent published in 2014 - IPC A61K31/496 A61K51/00 A61K103/10 

FIELD: chemistry.

SUBSTANCE: method of obtaining a reagent for preparation of a radiopharmaceutical based on technetium-99m-labelled ciprofloxacin consists in preparation of a hydrochloric acid solution of tin (II) chloride dehydratate with tin concentration 7 mg/ml by careful mixing of 0.07 mg of tin (II) chloride dehydratate and 0.2 ml of 1M hydrochloric acid and carrying out dissolution in an inert gas (argon) medium with further bringing the volume to 10 ml with distilled water after completion of dissolution, sampling 0.015-0.025 ml of the prepared solution and its mixing with 5-6 mg of a ciprofloxacin hydrochloride substance, the obtained solution is frozen at a temperature of liquid nitrogen, placed in a sublimator chamber and subjected to freeze drying at specified parameters of lyophiliser: T=-50°C, vacuum - 0.0015 Torr, for 20.5 hours, with further placement in the upper lyophilic chamber and after-drying for 5.5 hours at a temperature of+15°C.

EFFECT: increased term of the reagent application time due to increase of its stability.

1 dwg, 1 tbl, 1 ex