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(19)

(11)

2 569 107

(13)

(51)

IPC

C07K16/22(2006-01-01)

A61K39/395(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2011129204/10, 2009-12-14

(24)

Start date

2009-12-14

(22)

Actual filing date

2009-12-14

(45)

Published

2015-11-20

(72)

Inventor

Ul'Rikh BrinkmannRemko-Albert GripKlaus KalutsaAnita Kavl'EKristian KlajnJerg Tomas RegulaVerner Shojer

(73)

Holder

F.Khoffmann-Lja Rosh Ag

ANTIBODIES AGAINST HUMAN ANGIOPOIETIN-2 Russian patent published in 2015 - IPC C07K16/22 A61K39/395 A61P35/00

Abstract RU 2569107 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of biochemistry, in particular to antibodies against human angiopoietin-2, coding them nucleic acids and host cells. An antibody is characterised by the fact that it does not bind with human angiopoietin-1. Also claimed is a pharmaceutical composition, which contains the antibody against human angiopoietin-2, intended for cancer treatment, prevention of metastases or treatment of vascular diseases.

EFFECT: invention makes it possible to increase specificity, reduce toxicity and improve pharmacokinetic properties of antibodies against human angiopoietin-2.

13 cl, 13 dwg, 10 tbl, 9 ex

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RU 2 569 107 C2

Authors

Ul'Rikh Brinkmann

Remko-Albert Grip

Klaus Kalutsa

Anita Kavl'E

Kristian Klajn

Jerg Tomas Regula

Verner Shojer

Dates

2015-11-20—Published

2009-12-14—Filed