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(19)

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2 597 973

(13)

(51)

IPC

C07K16/22(2006-01-01)

C12N15/13(2006-01-01)

C12N15/63(2006-01-01)

A61K39/395(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2012143793/10, 2011-03-24

(24)

Start date

2011-03-24

(22)

Actual filing date

2011-03-24

(45)

Published

2016-09-20

(72)

Inventor

Bener MonikaImkhof-Yung ZabineKavle AnitaKettenberger GubertKlyajn KristianRegula Jorg TomasShefer VolfgangShantser Jyurgen MikhelShojer VernerShtubenraukh Kaj-GunnarTomas Markus

(73)

Holder

F. Khoffmann-Lya Rosh Ag

BISPECIFIC BIVALENT ANTI-VEGF/ANTI-ANG-2 ANTIBODIES Russian patent published in 2016 - IPC C07K16/22 C12N15/13 C12N15/63 A61K39/395 A61P35/00

Abstract RU 2597973 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to biochemistry, particularly, to bispecific bivalent antibody, which is specifically bound to human vascular endothelial growth factor (VEGF) and human angiopoietin-2 (ANG-2). Invention also discloses: a pharmaceutical composition for treating cancer related to the VEGF and ANG-2 containing a therapeutically effective amount of the said bispecific antibody, nucleic acid coding the said antibody, an expression vector containing the said nucleic acid, prokaryotic or eukaryotic host cell containing the said vector. Disclosed is a method of producing the said bispecific antibody.

EFFECT: invention provides effective treatment of VEGF- and ANG-2-mediated cancer.

9 cl, 15 dwg, 11 tbl, 13 ex

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RU 2 597 973 C2

Authors

Bener Monika

Imkhof-Yung Zabine

Kavle Anita

Kettenberger Gubert

Klyajn Kristian

Regula Jorg Tomas

Shefer Volfgang

Shantser Jyurgen Mikhel

Shojer Verner

Shtubenraukh Kaj-Gunnar

Tomas Markus

Dates

2016-09-20—Published

2011-03-24—Filed