METHOD FOR PREDICTION OF MULTIPLE ORGAN FAILURES FOR DETERMINING OPTIMAL TIME OF OSTEOSYNTHESIS IN CONCOMITANT AND MULTISYSTEM INJURY IN CHILDREN Russian patent published in 2015 - IPC G01N33/50 G01N33/68 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to paediatric traumatology, and can be used for treating fractures in the children suffering a multisystem injury. The optimal time of osteosynthesis is determined by measuring during the first post-injury hours the blood serum concentrations of S100 protein and cystatin C markers: the reference concentrations of S100 protein 312.2-587.8 ng/l and cystatin C 832.8-1062 ng/ml followed by a two-fold or higher increase for 1-4 days show manifestations of severe cerebral and renal metabolic disturbances; a general therapy is optimised, and a delayed osteosynthesis is performed at least 5-7 days later; the reference concentrations of S100 protein 103.8-292.0 ng/l and cystatin C 541-967 ng/ml followed by at least two-fold increase or decrease during the 1^st and following days show reversible functional cerebral and renal metabolic disturbances, whereas the 1^st-4^th post-injury day is considered to be the optimal time for osteosynthesis.

EFFECT: using the method enables detecting latent organ failures, assessing a degree of severity and performing the osteosynthesis as soon as reasonable that is expected to increase the clinical effectiveness in the concomitant and multisystem injury in the children.

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