FIELD: medicine.
SUBSTANCE: invention relates to medicine. Method for producing a microfiber material by successively mixing a solution of human serum albumin (HSA) in hexafluoroisopropanol (GPIP) and a drug (LS) in dimethylsulfoxide (DMSO) is described, after which the resulting solution is mixed with a solution of polycaprolactone (PCL) in GPIP. Drug is dissolved in DMSO, while the volume fraction of DMSO in the final polymer solution is 0.5–10.0 %, and the volume ratio of solutions PCL:HSA:LS is 1:1:(0.01–0.2). As drugs, paclitaxel, or sirolimus, or diclofenac is used.
EFFECT: microfiber material has increased elasticity, increased duration of drug release from the composition of the material.
4 cl, 2 dwg, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| BIOTRANSPLANT FOR JOINTS CARTILAGINOUS TISSUE DEFECTS RESTORING | 2015 |
|
RU2593011C1 |
| METHOD FOR PRODUCING SMALL-DIAMETER LOW-POROSITY VASCULAR PROSTHESES (VERSIONS) | 2014 |
|
RU2572333C1 |
| METHOD FOR MAKING SMALL-DIAMETER BLOOD VESSEL PROSTHESES BY ELECTROSPINNING AND DEVICE FOR ITS IMPLEMENTATION | 2018 |
|
RU2704314C1 |
| NEW DOSAGE FORM OF ECHINOCHROME A, A METHOD OF ITS PREPARATION AND USE | 2022 |
|
RU2800382C1 |
| METHOD OF MODIFYING SURFACE OF BIODEGRADABLE POLYMER MATERIALS | 2018 |
|
RU2699045C1 |
| STENT WITH DOUBLE DRUG RELEASE | 2010 |
|
RU2552086C2 |
| RAPAMICIN-RELEASING STENT | 2010 |
|
RU2563429C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING ELECTROHYDRODYNAMICALLY PRODUCED FIBERS, COMPOSITION HAVING IMPROVED RETENTION TIME AT SITE OF USE | 2016 |
|
RU2701513C2 |
| METHOD FOR MANUFACTURING SMALL-DIAMETER BLOOD VESSEL PROSTHESES BY ELECTROSPINNING AND A DEVICE FOR ITS IMPLEMENTATION | 2023 |
|
RU2805590C1 |
| BARE METAL STENT WITH MEDICATION-RELEASING RESERVOIRS | 2011 |
|
RU2573107C2 |
