ANTI-CANCER STEROID LACTONES UNSATURATED IN POSITION 7(8) Russian patent published in 2016 - IPC C07J19/00 C07J71/00 A61K31/585 A61P35/00 

Abstract RU 2572595 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a compound of general formula and its pharmaceutically acceptable salts and stereoisomers possessing anti-cancer activity, a based pharmaceutical composition, using them and a method of treating cancer with using them. In general formula I R1 and R2 are specified in hydrogen and halogen; R3, R5, R6, R7, R11, R12, R14 and R15 mean hydrogen; R4 means -OH; R8, R9 and R17 mean unsubstituted C1-C6 alkyl; R10 is specified in hydrogen, =O and ORb, wherein Rb means unsubstituted C1-C6 alkyl; R13 is specified in unsubstituted C1-C6 alkyl, OH-substituted C1-C6 alkyl and COH; R16 means -OH; and the line ----- represents either a bond, or an epoxy group.

EFFECT: producing pharmaceutically acceptable salts and stereoisomers possessing anti-cancer activity.

17 cl, 10 tbl, 5 ex

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RU 2 572 595 C2

Authors

Fernandes Rodriges Rokhelio

Rejes Benites Khose Fernando

Fransesch Sol'Oso Andres

Kuehvas Marchante Marija Del' Karmen

Dates

2016-01-20Published

2011-04-26Filed