ANTITUMOUR COMPOUNDS Russian patent published in 2011 - IPC C07D493/18 C07D493/22 C07D311/00 C07D323/00 A61K31/357 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel antitumour compounds of general formula I

, where R_1-16 are groups independently selected from hydrogen, protected or unprotected hydroxyl, C₁-C₂₄ alkyl, C₂-C₂₄ alkenyl, =O and OR_a, OCOR_a; X and Y are C₅-C₁₂ alkyl groups which are substituted with one or more C₁-C₆ alkyl groups, hydroxyl groups and/or tetrahydropyran which can be optionally substituted with an alkyl and/or OR_a group; R_a is independently selected from hydrogen and C₁-C₁₂ alkyl; and the dotted line denotes a double bond. The invention also relates to a method of producing said compounds, a pharmaceutical composition based on said compounds, having antitumour activity and use of formula I compounds to prepare a medicinal agent for treating cancer.

EFFECT: novel compounds which have cytotoxic activity and can be used to treat cancer are obtained and described.

15 cl, 2 ex, 2 tbl