PHENYLOXADIAZOLE DERIVATIVES AS PGDS INHIBITORS Russian patent published in 2016 - IPC C07C257/18 C07D271/06 C07D401/14 C07D413/14 A61K31/155 A61K31/4245 A61K31/506 A61P11/00 A61P11/02 A61P11/06 A61P27/02 A61P29/00 A61P37/08 

Abstract RU 2572608 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I), where R1 is hydrogen or C1-C6alkyl; R2 is hydrogen and R3 is hydroxy(C1-C6)alkyl; or pharmaceutically acceptable salts thereof. The invention also relates to methods of producing compounds of formula (I), intermediate compounds given in paragraphs 14-19 of the claim, and a method of producing an intermediate compound according to paragraph 17 of the claim.

EFFECT: obtaining compounds of formula as PGD2 synthase inhibitors and intermediate compounds for production thereof.

20 cl, 3 ex

Similar patents RU2572608C2

Title Year Author Number
PYRIMIDINE AMIDE COMPOUNDS AS PGDS INHIBITORS 2006
  • Oldous S'Juzan S.
  • Tszjan' Dzhon Tszytsi
  • Lu Tszin'Tsi
  • Ma Ljan
  • Mu Lan'
  • Manson Khehrri Rendall
  • Sejbol Dzheffri Stefen
  • Tkhurajratnam Sukantkhini
  • Vandjuzen Kristofer Loren
RU2420519C2
PIPERAZINE COMPOUND INHIBITING PROSTAGLANDIN-D-SYNTHASE 2010
  • Urade Josikhiro
  • Kitade Makoto
  • Sigeno Kazukhiko
  • Jamane Kejko
  • Tanaka Katsunao
RU2496778C2
PIPERIDINYLPYRAZOLOPYRIMIDINONES AND USE THEREOF 2015
  • Ellermann Manuel
  • Falot Gelle
  • Kankho Grande Iolanda
  • Khassfeld Jorma
  • Kintsel Tom
  • Kebberling Jokhannes
  • Bajer Kristin
  • Rerig Zuzanne
  • Shpertsel Mikhael
  • Shtampfuss Yan
  • Majer Imke
  • Kellnberger Maria
  • Burkkhardt Nils
  • Shlemmer Karl-Khajnts
  • Shtegmann Kristian
  • Shumakher Joakhim
  • Verner Mattias
  • Khajermann Jorg
  • Khengeveld Villem Yan
RU2713937C2
PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS 2008
  • Oldous S'Juzan S.
  • Fenni Majkl V.
  • Tszjan' Dzhon Ts.
  • Dzhon Stehnli
  • Mu Lan'
  • Pedgrift Brajan
  • Prajbish Dzhejms R.
  • Rokmen Barbara
  • Sejbol Dzheffri S.
  • Stokloza Grzigorz T.
  • Tkhurajratnam Sukantkhini
  • Vandjuzen Kristofer L.
RU2464262C2
PHENOXYMETHYL DERIVATIVES 2016
  • Khert Zherom
  • Khuntsiker Daniel
  • Kyune Kholger
  • Lyubbers Tomas
  • Martin Rajner E.
  • Mattej Patritsio
  • Najdkhart Verner
  • Rikhter Khans
  • Rudolf Markus
  • Pinar Emmanyuel
RU2746481C1
2,6-SUBSTUTED-4-MONOSUBSTITUTED AMINO-PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS 2005
  • Lim Sungtaek
  • Kharris Kejt Dzhon
  • Stefani Dehvid
  • Gardner Charl'Z Dzh.
  • Tsao Bin
  • Boffi Rehj
  • Gillespi Timoti A.
  • Agiar Zhuasi K.
  • Khant Khejzel Dzh.
  • Desho Ehl'Za A.
RU2417990C2
2-(PHENYL OR PYRID-3-YL)AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF LEUCINE-RICH REPEATING KINASE 2 (LRRK2) FOR TREATMENT OF PARKINSON'S DISEASE 2012
  • Bejker-Glenn Charlz
  • Chembers Mark
  • Chan Brajan K.
  • Estrada Entoni
  • Svini Zakari Kevin
RU2647849C2
NEW PHOSPHORAMIDATE NUCLEOSIDE DERIVATIVES AND APPLICATION THEREOF 2014
  • Van Yun
  • Chzhao Liven
  • Chzhan Syan
  • Bi Shen
  • Gao Ipin
  • Chen Khunyan
  • Van Dechzhun
  • Nan Yan
  • Chzhan Tsan
  • Li Yujsyu
  • Chzhan Di
RU2621709C2
2,6-SUBSTITUTED-4-MONOSUBSTITUTED AMINOPYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS 2007
  • Stefani Dehvid
  • Kharris Kit Dzhon
  • Gillespi Timoti Alan
  • Gardner Charl'Z Dzh.
  • Agiar Zhuasi K.
RU2431631C2
COMPOUND HAVING AGONISTIC ACTIVITY AGAINST GPR119, METHOD FOR ITS PREPARATION, AND PHARMACEUTICAL COMPOSITION CONTAINING IT AS AN EFFECTIVE COMPONENT 2015
  • Yang Jae Sung
  • Baek Gye Rim
  • Kim Yoon Jung
  • Ahn Chi Young
  • Lee Jae Young
  • Jung Il Hoon
  • Kim Mi Kyung
  • Kang So Mi
  • Lee Hyo Ju
  • Chae Yu Na
  • Cheong Ye Hwang
  • Kim Tae Hyoung
  • Yang Eun Kyoung
  • Son Moon Ho
  • Shin Chang Yell
RU2670197C1

RU 2 572 608 C2

Authors

Vandjuzen Kristofer L.

Uehjbert Frants Dzh.

Dzhill Kharpel S.

Li Dzhordzh

Khillegass Andrea

Dates

2016-01-20Published

2010-10-07Filed