FIELD: chemistry.
SUBSTANCE: invention relates to novel crystalline form of ingenol mebutate, characterised by FTIR-ATR spectrum, demonstrating peaks in spectrum of frustrated total internal reflection with frequencies at 3535, 2951, 1712, 1456, 1378, 1246, 1133, 1028 and/or 956 cm-1 (±3 cm-1), and curve of which, obtained by means of differential scanning calorimetry, demonstrates jump at temperature 153±5°C, as well as to methods of its obtaining and its application for treatment of skin lesions.
EFFECT: claimed invention relates to conversion of amorphous ingenol mebuate (ingenol-3-angelate, PEP005) into novel crystalline form, which has high purity degree and is characterised by data of X-ray crystallography (XRC) of monocrystal, infrared spectroscopy of frustrated total internal reflection with Fourier transform (FTIR-ATR) and differential calorimetry (DSC).
37 cl, 1 dwg, 4 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| THERAPEUTIC AGENT FOR TREATMENT OF PRECANCEROUS SKIN LESIONS | 2004 |
|
RU2366447C2 |
| INGENOL-3-ACYLATES I | 2011 |
|
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| MILD DOSAGE FORM FOR TREATING ONCOLOGICAL DISEASES | 2020 |
|
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| 3-ACYLINGENOLES II | 2011 |
|
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| PHARMACEUTICAL COMPOSITION FOR TREATING CANCER | 2012 |
|
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| INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | 2011 |
|
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| TREATING OR PREVENTING SEBORRHEIC KERATOSIS USING ARTEMISININ AND DERIVATIVES THEREOF | 2015 |
|
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| SOLID FORMS OF 2-(5-(4-(2-MORPHOLINOETHOXY)PHENYL)PYRIDINE-2-IL)-N-BENZYLACETAMIDE | 2018 |
|
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| INTERMEDIATE CHEMICAL COMPOUNDS AND METHODS FOR PRODUCING COMPOUNDS | 2013 |
|
RU2635359C2 |
| COMPOSITIONS OF EXTRACELLULAR VESICLES (EV) OF PLANT ORIGIN AND THEIR USE | 2020 |
|
RU2812553C2 |
