3-ACYLINGENOLES II Russian patent published in 2016 - IPC C07C69/74 C07C69/75 C07C69/753 C07C229/56 A61K31/215 A61K31/216 A61K31/245 A61P35/00

Abstract RU 2575350 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: in formula (I) R represents C6-10aryl substituted by one or more substitutes independently specified in R3; or R represents (C₃-C₉)-cycloalkyl or (C₆)-cycloalkenyl each of which may be optionally substituted by one or more substitutes optionally specified in R4; R3 represents halogen, hydroxyl; or R3 represents (C₁-C₄)-alkyl, (C₆)-aryl or R3 represents -NRaCORb, -ORa or -NRdRe; R4 represents cyano; or R4 represents (C₁-C₄)-alkyl, or R4 represents -COORc; Ra and Rb independently represent hydrogen, (C₁-C₄)-alkyl, (C₂-C₄)-alkenyl, (C₆)-aryl; Rc represents (C₁-C₄)-alkyl, Rd and Re independently represent hydrogen, (C₁-C₄)-alkyl, (C₆)aryl, (C₆)aryl(C₁-C₄)-alkyl. The invention also refers to a pharmaceutical composition containing the above compound.

EFFECT: invention refers to the compound of structural formula I, which can be used to prevent, treat or reduce an intensity of symptoms of a disease or condition susceptible to IL-8 keratinocyte release stimulation, susceptible to neutrophil oxidative burst stimulation or susceptible to necrosis induction.

26 cl, 345 ex

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RU 2 575 350 C2

Authors

Grueh-Serensen Gunnar

Ljan Sifu

Khegberg Tomas

Monsson Kristoffer

Vedse Per

Dates

2016-02-20—Published

2011-12-22—Filed