FIELD: medicine.
SUBSTANCE: invention refers to medicine and concerns a targeted drug delivery. Improving the therapeutic compound penetration through a cell layer comprising epithelial cells requires using a microneedle. A microneedle surface comprises a number of nanostructures formed on this surface and arranged as a pre-formed pattern. At least a part of nanostructures has a cross-section size of less than approximately 500 nanometres and more than approximately 5 nanometres.
EFFECT: method provides improving the therapeutic compound penetration through the epithelium by increasing an area of needle and tissue contact, as well as by changing the structure of an intercellular junction.
15 cl, 10 ex, 10 tbl, 48 dwg
