NEW AMIDE DERIVATIVES AND USING THEM AS MEDICINAL PRODUCT Russian patent published in 2016 - IPC C07D401/14 C07D403/10 C07D403/14 C07D413/14 C07D417/10 C07D417/14 C07D295/192 C07D471/04 A61K31/496 A61K31/437 A61K31/445 A61K31/454 A61K31/4545 A61K31/501 A61K31/506 A61K31/5377 A61K31/541 A61P1/04 A61P19/00 A61P19/02 A61P37/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to an amide derivative of formula (I)

exhibiting the property of inhibiting proMMP-9 production, as well as to a based pharmaceutical composition and medicinal product on it's base and an agent for inhibiting MMP-9 production. In general formula (I), A represents phenylene or 6-merous heteroarylene presented by the following formula R¹ represents C₁-C₆alkyl or C₃-C₆cycloalkyl; R² represents aC₁-C₆alkyl optionally substituted by a halogen atom, or C₃-C₆cycloalkyl; R³ represents a hydrogen atom or C₁-C₆alkyl; each R^4a, R^4b and R^4c represents a hydrogen atom; W represents a bond, C₁-C₆alkylene or C₃-C₆cycloalkyldiene; X represents a nitrogen atom (if Y represents a bond, The nitrogen atom can be oxidised to form N-oxide); Y represents a bond; m is equal to 1 or 2; Z¹ represents a carbon atom or a nitrogen atom, each Z² and Z³ represents a carbon atom; R^a and R^b together with an adjacent atom form a nitrogen-containing cyclic group presented below: , or , which is optionally substituted by C₁-C₆alkyl optionally substituted by a hydroxyl group or C₁-C₆alkoxy or oxo.

EFFECT: producing new amide derivatives.

12 cl, 5 tbl, 843 ex