COMPOUNDS APPLICABLE FOR TREATING PREMATURE AGEING AND PARTICULARLY PROGERIA Russian patent published in 2016 - IPC C07D401/12 C07D213/74 C07D215/38 C07D241/44 C07D403/12 A61K31/444 A61P43/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to using a compound of formula

or any of its pharmaceutically acceptable salts, wherein: means an aromatic ring, wherein V represents C or N, and when V represents N, V is found in meta- or para-position in relation to Z; R independently represents a hydrogen atom, a halogen atom or a group specified in -CN group, hydroxyl group, -COOR₁ group, (C₁-C₃)fluoralkyl group, (C₁-C₃)fluoralkoxy group, -NO₂ group, -NR₁R₂ group, (C₁-C₄)alkoxy group, phenoxy group and (C₁-C₃)alkyl group, wherein the above alkyl is optionally substituted by a monosubstituted hydroxyl group; R₁ and R₂ optionally represents a hydrogen atom or (C₁-C₃)alkyl group, n is equal to 1, 2 or 3, n' is equal to 1 or 2, R' represents a hydrogen atom, a halogen atom or a group specified in (C₁-C₃)alkyl group, -NO₂ group, -NR₁R₂ group, morpholinyl or morpholino group, N-methylpiperazinyl group, (C₁-C₃)fluoralkyl group and (C₁-C₄)alkoxy group, R" represents a hydrogen atom, Z, Y, X, W, T, U represent N or C, and wherein maximum four of V, T, U, Z, Y, X and W groups represent N, and at least one of T, U, Y, X and W groups represents N, or any of its pharmaceutically acceptable salts for producing a medicinal agent for preventing, inhibiting or treating pathological or non-pathological conditions related to premature ageing, specified in Hutchinson-Gilford progeria syndrome (HGPS), progeria, premature ageing caused by HIV infection, muscular dystrophy, Charcot-Marie-Tooth disease, Werner syndrome, insulin-resistant type II diabetes mellitus, osteoporosis and skin ageing, restrictive dermopathy. Besides, the invention refers to using specific compounds, to new quinoline derivatives, a pharmaceutical composition based on the new quinoline derivative.

EFFECT: there are produced new quinoline derivatives, and new biological activity of known compounds is also stated.

11 cl, 6 dwg, 2 tbl, 24 ex