FIELD: biotechnologies.
SUBSTANCE: disclosed is recombinant plasmid pCpG-CytDA/upp with nucleotide sequence SEQ ID NO: 1, providing expression of hybrid protein citozindezaminaze E.coli-uracilphosforybozyl transferase. Disclosed is recombinant plasmid pCpG-CytDA/upp/VP22 with nucleotide sequence SEQ ID NO: 2, providing expression of hybrid protein citozindezaminaze e.coli-uracilphosforybozyl transferase-protein VP22 of individual. Also disclosed is composition containing mesenchymal stem/stromal cells, in which there is one of above plasmids.
EFFECT: group of inventions provides higher efficiency and safety of using mesenchymal stem/stromal cells expressing citozindezaminaze for therapy of tumours of various etiologies.
7 cl, 4 dwg, 2 tbl, 5 ex
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