FIELD: medicine.
SUBSTANCE: invention refers to medicine, namely to a method for evaluating a risk of a pregnancy failure. Substance of the method consists in the fact that biomarkers for evaluating the risk of the pregnancy failure are the concentrations of hypoxanthine, xanthine, uric acid; that is ensured by diluting blood serum in distilled water with removing proteins masking the detection of the biomarkers for evaluating the risk of the pregnancy failure. The biomarkers for evaluating the risk of the pregnancy failure are separated in a deposited fraction by means of reverse-phase liquid chromatography with the use of a buffer solution containing an ion-paired agent; hypoxanthine, xanthine, uric acid signal is recorded in the ultraviolet spectrum. The concentrations are calculated. If the uric acid concentration is more than 600 mcmol/l, the risk of pre-eclampsia is stated, whereas a hypoxanthine/xanthine concentration ratio of more than 0.9 shows the risk of premature delivery.
EFFECT: using the declared method enables providing the more effective evaluation of the risk of the pregnancy failure.
5 cl, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREDICTING THE RISK OF DEVELOPMENT OF PRE-ECLAMPSIA IN WOMEN OF DIFFERENT SOMATOTYPES | 2018 |
|
RU2679111C1 |
| METHOD OF PREDICTING THE RISK OF PRE-ECLAMPSIA IN PREGNANT WOMEN WITH TYPE 1 DIABETES MELLITUS | 2022 |
|
RU2800717C1 |
| METHOD OF PREDICTING THE RISK OF PRE-ECLAMPSIA IN PREGNANT WOMEN WITH TYPE 2 DIABETES MELLITUS | 2022 |
|
RU2800716C1 |
| METHOD FOR DIAGNOSING PLACENTA INGROWTH INTO UTERINE WALL IN WOMEN WITH PLACENTA PREVIA | 2021 |
|
RU2771874C1 |
| PREDICTION OF PREECLAMPSIA BASED ON DETERMINING EXTRACELLULAR FETAL DNA IN MATERNAL BLOOD WHEN SCREENING THE FIRST TRIMESTER OF PREGNANCY | 2019 |
|
RU2697845C1 |
| METHOD OF DETERMINING PURINES AND PYRIMIDINES IN HUMAN BIOLOGICAL FLUIDS | 2012 |
|
RU2620155C2 |
| METHOD OF PROLONGING PREGNANCY IN EARLY PRE-ECLAMPSIA | 2023 |
|
RU2803574C1 |
| METHOD FOR DIFFERENTIAL DIAGNOSIS OF ISOLATED PREECLAMPSIA AND PREECLAMPSIA, DEVELOPING ON THE BACKGROUND OF UNDIAGNOSED CHRONIC ARTERIAL HYPERTENSION | 2019 |
|
RU2713436C1 |
| METHOD OF PREDICTING THE DEVELOPMENT OF HYPERTENSIVE DISORDERS DURING PREGNANCY IN THE MIDDLE RISK GROUP AMONG THE WOMEN WHO UNDERWENT COMBINED SCREENING OF THE 1ST TRIMESTER | 2023 |
|
RU2803010C1 |
| METHOD FOR PREDICTION OF RISK OF DEVELOPING PREECLAMPSIA | 2023 |
|
RU2817206C1 |
