FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology and represents peptide which has amino acid sequence consisting of adjacent amino acids obtained from protein WT1, and induces WT1-specific T-helper cells by binding with class II MHC molecule. Such amino acid sequence is selected from group consisting of amino acid sequence shown in SEQ ID NO: 3; amino acid sequence shown in SEQ ID NO: 4; amino acid sequence shown in SEQ ID NO: 5. Invention also relates to expression vector containing polynucleotide coding peptide, peptide antibodies, pharmaceutical composition containing peptide, method of treating cancer by administering peptide to individual.
EFFECT: invention enables to obtain effective agent for induction of WT1-specific T-helper cells by binding with class II MHC molecule and use thereof for treating cancer.
17 cl, 18 dwg, 9 tbl, 5 ex
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