ORGANIC COMPOUNDS Russian patent published in 2020 - IPC C07D471/14 A61K31/4985 A61K31/5383 A61P25/00 A61P25/28

Abstract RU 2733975 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to deuterated heterocyclic condensed gamma-carbolines of formulas I, II, III, in free or salt form, as well as their pharmaceutical compositions based on said compounds, to methods of treating diseases associated with 5-HT_2A receptor, a serotonin transporter (SERT) and/or routes involving dopamine D₁/D₂ signaling system, and/or treating residual symptoms.

EFFECT: there are prepared and described compounds which demonstrate improved metabolic stability and can be used in treating disorders of the central nervous system.

20 cl, 2 tbl, 7 ex

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RU 2 733 975 C2

Authors

Yao, Wei

Li, Peng

Dates

2020-10-08—Published

2017-03-24—Filed