FIELD: chemistry.
SUBSTANCE: group of inventions relates to a mutant channel rhodopsins and to their respective applications. Light-activated ion channel contains an amino acid sequence which is at least 70 % homologus to amino acid sequence positions 1-309 SEQ ID NO: 1 (CHOP-2) and which contains a substitute in position corresponding to L132 in SEQ ID NO: 1.
EFFECT: higher channel polarity and conductivity of calcium increases at least twice as compared to wild type CHOP-2, as specified Fura-2 rendering on HEK293 cells.
16 cl, 7 dwg, 1 tbl
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|---|---|---|---|
| INHIBITING GENE EXPRESSION IN INSECT PESTS | 2018 |
|
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| VARIANT CD3 BINDING DOMAINS AND THEIR USE IN COMBINATION THERAPY FOR TREATMENT OF DISEASES | 2019 |
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|
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| MULTISPECIFIC ANTIBODIES, MULTISPECIFIC ACTIVATED ANTIBODIES AND METHODS OF USE THEREOF | 2014 |
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RU2815683C2 |
| ACTIVATED POLYPEPTIDES OF INTERLEUKIN-2 AND METHODS OF USE THEREOF | 2019 |
|
RU2826454C2 |
| HYBRID PROTEINS OF sPD-1-Fc VARIANT | 2019 |
|
RU2785993C2 |
| NOVEL FUSION PROTEINS SPECIFIC FOR CD137 AND GPC3 | 2020 |
|
RU2814653C2 |
| C5 ANTIBODIES AND THEIR APPLICATION METHODS | 2015 |
|
RU2746356C2 |
| MULTISPECIFIC ANTIBODIES, MULTISPECIFIC ACTIVATED ANTIBODIES AND METHODS OF THEIR APPLICATION | 2014 |
|
RU2727836C2 |
| ANTIBODY CAPABLE OF BINDING TO THYMIC STROMAL LYMPHOPOIETIN, AND USE THEREOF | 2020 |
|
RU2825304C2 |
