COMPOUNDS FOR BINDING TO PLATELET SPECIFIC GLYCOPROTEIN IIB/IIIA AND THEIR USE FOR IMAGING THROMBI Russian patent published in 2016 - IPC C07D401/06 C07D401/12 C07D401/14 A61K31/4409 A61K49/00 A61K51/00 

FIELD: chemistry.

SUBSTANCE: invention relates to fluorine containing compounds of formula III:

,

where R³ is selected from group comprising H, F, CN and NO₂; R⁷ is selected from group comprising Y, -O(CH₂)_n-Y, -(OCH₂CH₂)_m-Y, Z, -OCH₂-Z; -CH₂-CH₂-Z, -CH=CH-Z and -C≡C-Z; X is selected from CH or N; Y is selected from ¹⁸F or F; Z is a group

,

where * indicates the atom of connection of Z; R⁵ is selected from group comprising H, CN and NO₂; R⁸ is selected from group comprising Y and -O(CH₂)_n-Y; n is a 1-3; and m is a 2-3; including E-and Z-isomers and diastereomers, mixtures thereof, and any pharmaceutically acceptable salt or their complex, as well as methods for production thereof, intermediate synthesis compounds.

EFFECT: use of salts as diagnostic agents, especially for imaging thrombi.

14 cl, 6 tbl, 55 ex