FIELD: pharmaceutics.
SUBSTANCE: invention relates to a method of producing novel 5-hetarylmethylenepyrimidine-2,4,6-triones of general formula III (a-i). In general formula (III) 
Het denotes a) benzofuran-2-yl; b) benzofuran-5-yl; c) 5-bromfuran-2-yl; d) 1,3-benzothiazole-2-yl; e) 2,1,3-benzooxadiazol-5-yl; f) 1,3-dimethyl-5-morpholinopyrazol-4-yl; g) 5-acetoxymethylfuran-2-yl; h) thiophene-2-yl; i) benzothiophene-2-yl. Method of producing compounds of formula III (a-i) involves condensation (while heated) of pyrimidine-2,4,6-trion I with the corresponding heterocyclic aldehyde of formula II (a-i) in iso-butanol. Preferably the process is carried out during 45 minutes at equimolar amount of compounds I and II. Process is carried out as per the following scheme 
.
EFFECT: invention can be used as a potential anticonvulsant and hypnotic agent.
1 cl, 1 tbl, 13 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
RU2572081C1 |
| NEW DIAMIDES PYRIMIDIN-4,6 OF DICARBOXYLIC ACID FOR SELECTIVE INHIBITION OF COLLAGENASES | 2003 |
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|
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|
RU2647240C1 |
| NOVEL COMPOUNDS AND USE THEREOF IN THERAPY | 2004 |
|
RU2412190C2 |
| 1'-ARYL-4'-HYDROXY-3'-CYNNAMOYL-2H,4H-SPIRO[FURO[3,2-c]CHROMEN-3,2'-PYRROL]-2,4,5'(1'H)-TRIONES EXHIBITING ANALGESIC ACTIVITY, AND METHOD FOR PRODUCING THEM | 2014 |
|
RU2577523C2 |
| DERIVATIVES OF BENZAMIDINE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION | 1998 |
|
RU2194044C2 |
| APPLICATION OF ANTIFUNGAL AGENT BASED ON 2-((4-R1-5-R2-3-(ETHOXYCARBONYL)THIOPHENE-2-IL)AMINO)-4-OXO-4-R3-BUT-2-ENO ACIDS IN RELATION TO CANDIDA ALDICANS | 2021 |
|
RU2770598C1 |
