FIELD: chemistry.
SUBSTANCE: invention relates to improved method of obtaining 5-(arylmethylene)hexahydropyrimidine-2,4,6-triones of general formula III. Compounds can be applied as potential antispasmodic and soporific means. Compounds of formula III a-f 
where IIIa R = H; b R = 4-CH3O; c R = 4-Me2N; d R = 4-Cl; e R = 3-NO2; f R = 2-OH, are obtained by reaction of condensation at heating of 2,4,6-pyrimidinetrione I for 45 minutes with 1,1-fold excess of aromatic aldehydes II a-f in ethanol. Method is realised by the following scheme: 
Method makes it possible to obtain products with stable high output 82-92%.
EFFECT: changing parameters of method conditions leads to reduction in output of target products.
1 tbl, 10 ex
| Title |
Year |
Author |
Number |
| METHOD FOR PRODUCTION OF 4-ARYL-2,7,9-TRIAZASPIRO[4,5]DECANE-6,8,10-TRIONS |
2016 |
- Tyrkov Aleksej Georgievich
- Yurtaeva Ekaterina Alekseevna
|
RU2635105C1 |
| METHOD OF PRODUCING 5-HETARYLMETHYLENEPYRIMIDINE-2,4,6-TRIONES |
2015 |
- Tyrkov Aleksej Georgievich
- Yurtaeva Ekaterina Alekseevna
|
RU2598607C1 |
| METHOD OF PRODUCING β-KETOSULPHONES AND 1,4-DIKETONES |
2011 |
- Serdjuk Ol'Ga Vladimirovna
- Butin Aleksandr Valerianovich
- Abaev Vladimir Tajmurazovich
|
RU2455271C1 |
| (1Z,3Z)-4-ARYL-4-HYDROXY-1-(3,3-DIALKYL-3,4-DIHYDROISOQUINOLIN-1(2N)-YLIDENE)-BUT-3-EN-4-ONES AND METHOD OF PRODUCING SAID COMPOUNDS |
2008 |
- Khalturina Valerija Vladislavovna
- Shkljaev Jurij Vladimirovich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragipovich
|
RU2374231C1 |
| 1,6'-DIARYL-3-AROYL-4-HYDROXY-1',3'-DIMETHYLSPIRO[PIRROLE-2,5'-PYRROLO[2,3-d]PYRIMIDINE]-2',4',5(1H,1'H,3'H)-TRIONES AND METHOD FOR PRODUCTION THEREOF |
2012 |
- Silajchev Pavel Sergeevich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2502738C2 |
| 1,1'-DIARYL-3'-AROYL-4'-HYDROXY-1H-SPIRO [INDENO[1,2-b]PYRROL-3,2'-PYRROL]-2,4,5'-(1'H)-TRIONES AND METHOD OF THEIR OBTAINING |
2011 |
- Bubnov Nikolaj Vladimirovich
- Denislamova Ekaterina Sergeevna
- Makhmudov Ramiz Ragibovich
- Maslivets Andrej Nikolaevich
|
RU2467011C1 |
| 3-AROYL-2-HYDROXY-2-(2-OXOCYCLOALKYL)PYRROLO[2,1-C][1,4]BENZOXAZINE-1,4(2H)-DIONES HAVING ANALGESIC ACTIVITY AND METHODS FOR PRODUCTION THEREOF |
2014 |
- Maslivets Andrej Nikolaevich
- Stepanova Ekaterina Evgen'Evna
- Makhmudov Ramiz Ragibovich
|
RU2564440C1 |
| (2Z,5Z-1-ARYL-3-HYDROXY-5-(3,3-DIMETHYL-3,4-DIHYDROISOQUINOLIN-1(2N)-YLIDENE)-PENT-2-ENE-1,4-DIONES AND METHOD OF PRODUCING SAID COMPOUNDS |
2008 |
- Khalturina Valerija Vladislavovna
- Maslivets Andrej Nikolaevich
- Shkljaev Jurij Vladimirovich
|
RU2374232C1 |
| METHOD OF SYNTHESIS OF 1-(3-ALKOXY-2- CARBAMOYLHYDROXYPROPYL) -(1H,3H,5H) -PYRIMIDINE- 2,4,6-TRIONE AND DERIVATIVES OF (1H,3H,5H)- PYRIMIDINE-2,4,6- TRIONE |
1991 |
- Bernar Zigfrid[Fr]
- Indrzhikh Vakhta[Ch]
- Karel Val'Ter[Ch]
- Stefan Khugentobler[Ch]
|
RU2050353C1 |
| N-ARYL-2,3-DIAROYL-8,10-DIMETHYLPYRIDO[2',3',3,4]PYRAZOLO[1,5-α]PYRIMIDINE-4-CARBOXAMIDE AND METHOD FOR PREPARING THEM |
2012 |
- Silajchev Pavel Sergeevich
- Maslivets Andrej Nikolaevich
|
RU2478640C1 |
