FIELD: chemistry.
SUBSTANCE: invention relates to organic synthesis, specifically to a method of producing 5-hetarylmethylidene-2-sulphonylidene dihydropyrimidine-4,6(1H,5H)-diones, which can be used as potential anticonvulsants and hypnotics. A method of producing compounds of formula III (a-e), 
, where Het denotes thiophen-2-yl; indol-3-yl; benzofuran-2-yl; 5-bromfuran-2-yl; 1,3-benzothiazol-2-yl is carried out by condensation while boiling in ethanol for 45 minutes, without using other catalysts, 2-sulphonylidene dihydropyrimidine-4,6(1H,5H)-dione with equimolar amount of corresponding heterocyclic aldehydes.
EFFECT: providing a simple method of producing desired compounds with high output of 85-92%.
1 cl, 1 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 5-HETARYLMETHYLENEPYRIMIDINE-2,4,6-TRIONES | 2015 |
|
RU2598607C1 |
| METHOD OF OBTAINING 5-(ARYLMETHYLENE)HEXAHYDROPYRIMIDINE-2,4,6-TRIONES | 2014 |
|
RU2572081C1 |
| METHOD OF PRODUCING 5-SUBSTITUTED OXAZOLIDINE-2,4-DION | 0 |
|
SU1264841A3 |
| N-ARYL-2,3-DIAROYL-8,10-DIMETHYLPYRIDO[2',3',3,4]PYRAZOLO[1,5-α]PYRIMIDINE-4-CARBOXAMIDE AND METHOD FOR PREPARING THEM | 2012 |
|
RU2478640C1 |
| 1,6'-DIARYL-3-AROYL-4-HYDROXY-1',3'-DIMETHYLSPIRO[PIRROLE-2,5'-PYRROLO[2,3-d]PYRIMIDINE]-2',4',5(1H,1'H,3'H)-TRIONES AND METHOD FOR PRODUCTION THEREOF | 2012 |
|
RU2502738C2 |
| METHOD OF PRODUCING INDOLO[2,3]PYRROLO[3,4-c]CARBAZOLE-5,7-DIONES N-GLYCOSIDES EXHIBITING CYTOTOXIC AND ANTICANCER ACTIVITY | 2009 |
|
RU2427585C9 |
| METHOD OF PRODUCING 5-SUBSTITUTED OXAZOLIDINE-2,4-DIONES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS WITH ALKALI METALS OR ACID-ADDITIVE SALTS AS RACEMATE OR OPTICALLY ACTIVE ENANTIOMERS | 0 |
|
SU1194275A3 |
| METHOD FOR PRODUCING 1H-BENZO[F]CHROMEN-2-YL(ARYL)KETONES | 2015 |
|
RU2633368C2 |
| METHYL 4-ARYL-1-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-2,3-DIOXO-2,3,5,10 -TETRAHYDROBENZO[b]PYRROLO[2,3-e][1,4]DIAZEPINE-10a(1H)-CARBOXYLATES EXHIBITING ANALGESIC ACTIVITY, AND METHOD OF THEIR PREPARATION | 2022 |
|
RU2811413C1 |
| METHOD OF SYNTHESIS OF TETRAHYDROBENZIMIDAZOLE DERIVATIVE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT | 1990 |
|
RU2024516C1 |
