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(19)

RU

(11)

2 502 738

(13)

C2

(51)

IPC

C07D487/20(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2012103977/04, 2012-02-07

(24)

Start date

2012-02-07

(22)

Actual filing date

2012-02-07

(45)

Published

2013-12-27

(72)

Inventor

Silajchev Pavel SergeevichMaslivets Andrej NikolaevichMakhmudov Ramiz Ragibovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Natsional'Nyj Issledovatel'Skij Universitet"Obshchestvo S Ogranichennoj Otvetstvennost'Ju

1,6'-DIARYL-3-AROYL-4-HYDROXY-1',3'-DIMETHYLSPIRO[PIRROLE-2,5'-PYRROLO[2,3-d]PYRIMIDINE]-2',4',5(1H,1'H,3'H)-TRIONES AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2013 - IPC C07D487/20 A61P29/00 

Abstract RU 2502738 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of the class of spiro[pyrrole-2,5'-pyrrolo[2,3-d]pyrimidine, particularly 1,6'-diaryl-3-aroyl-4-hydroxy-1',3'-dimethylspiro[pyrrole-2,5'-pyrrolo[2,3-d]pyrimidine]-2',4',5'(1H,1H',3'H)-triones, having a structural formula given below, as well as a method for production thereof. In the structural formula of compounds disclosed herein, , Ar1=Ph, C6H4Me-4; Ar2=Ph, C6H4Me-4, C6H4OMe-4, C6H4Br-4. The method of producing the compounds involves reacting 1-aryl-4,5-diaroyl-1H-pyrrole-2,3-diones with 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione in a medium of an inert aprotic solvent. The process is normally carried out at temperature of 82-84°C, using pure dichloroethane as the solvent.

EFFECT: compounds have analgesic activity and can be used in pharmacology as potential medicaments, as well as primary products for synthesis of novel heterocyclic systems.

4 cl, 1 tbl, 2 dwg, 2 ex

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RU 2 502 738 C2

Authors

Silajchev Pavel Sergeevich

Maslivets Andrej Nikolaevich

Makhmudov Ramiz Ragibovich

Dates

2013-12-27—Published

2012-02-07—Filed

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