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(19)

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2 599 990

(13)

(51)

IPC

C07J63/00(2006-01-01)

(21) (22)

Application

2015145560/04, 2015-10-22

(24)

Start date

2015-10-22

(22)

Actual filing date

2015-10-22

(45)

Published

2016-10-20

(72)

Inventor

Levdanskij Vladimir AleksandrovichLevdanskij Aleksandr VladimirovichKuznetsov Boris Nikolaevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Khimii I Khimicheskoj Tekhnologii Sibirskogo Otdeleniya Rossijskoj Akademii Nauk So Ran)

METHOD OF PRODUCING BETULINOL DIACETATE Russian patent published in 2016 - IPC C07J63/00

Abstract RU 2599990 C1

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a method of producing betulinol diacetate, having anti-tumour activity. Betulinol diacetate is being produced by acetylation of betulinol with acetic acid in the presence of catalytic amounts of orthophosphoric acid in the toluene medium with removal of water, produced during the reaction. Then, the produced reaction mass is being concentrated under vacuum, residue is being dissolved with water, filtered, dried, recrystallized from ethanol.

EFFECT: reduced consumption of acetic and orthophosphoric acids and multiple use of toluene, removing during extraction of betulinol diacetate.

1 cl, 1 ex

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RU 2 599 990 C1

Authors

Levdanskij Vladimir Aleksandrovich

Levdanskij Aleksandr Vladimirovich

Kuznetsov Boris Nikolaevich

Dates

2016-10-20—Published

2015-10-22—Filed