METHODS FOR DETECTING ANTI-HE4 ANTIBODIES AND METHODS OF DIAGNOSIS AND/OR PROGNOSIS OF CONDITIONS ASSOCIATED WITH HE4-EXPRESSING CELLS Russian patent published in 2016 - IPC G01N33/574 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to oncology, and can be used for detecting the risk of the stage I/II of ovarian carcinoma. To perform it the method includes detection of anti-he4 antibodies in a biological sample obtained from the subject. Meanwhile the presence or amount of anti-he4 antibodies in the biological sample indicates that the subject is at risk of developing of the stage I/II of ovarian carcinoma. Group of inventions also relates to a method of an efficiency control of the treatment of a human with a malignant tumor, receiving the therapeutic treatment for the expressing he4 tumor, and a kit to detect the presence of he4-expressing cells in a subject of individual. Using this group of inventions allows to detect an early stage I/II of ovarian carcinoma by detecting anti-he4 antibodies expression, as well as to provide the control of efficiency of anticancer therapy, where the increase of the level of anti-he4 autoantibodies serves as an indicator of response to the treatment of a patient with the ovarian malignant tumor.

EFFECT: detecting the risk of the stage I/II of ovarian carcinoma.

24 cl, 4 ex, 2 dwg, 3 tbl