FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, pharmacology, pharmaceutics and describes methods and compositions for treating and/or preventing hyperuricemia (HU) or metabolic disorders associated with HU. Such disorders include: acute or chronic gout, its sudden aggravations, gouty arthritis, urate nephrolithiasis, gouty nephropathy. Methods involve administering of therapeutically effective amount of diacerein, rhein or their pharmaceutically acceptable salt, analogue, prodrug or active metabolite. Wherein said compound reduces blood uric acid levels. Therapeutically effective amount of compound can be equivalent to 10-200 mg of diacerein base a day. Methods of treating with said compounds can be used in patients with poor tolerance to anti-inflammatory or urate-lowering agents.
EFFECT: group of inventions provides advantages in reducing or preventing HU due to ability of diacerein and its said analogues, salt, prodrug, active metabolite, even in form of single agent therapy to reduce blood uric acid level to normal and below, causing no side effects, refractory to therapy as compared with previously known agents against HU.
22 cl, 2 dwg, 2 ex, 2 tbl
